product Connective Tissue Diseases

Identification of the lupus erythematosus (LE) cell in 1948 provided physicians with a relatively specific laboratory test to aid in the diagnosis of systemic lupus erythematosus (SLE). More recently, determining the presence or absence of particular autoantibodies influences the confidence with which a diagnosis is made.

It has been found that among the major systemic rheumatic disorders, each exhibits a rather distinct and unique profile of ANA's characteristic of the particular disorder.

dsDNASm AntigenHistonesSS-ASS-B RNPScl-70NucleolarCentromereJo1
Systemic Lupus Erythematosus (SLE)^50-60%30%60% 30-40%15%30-40%----
Mixed connective Tissue Disease (MCTD)--- --^90-100%----
Drug-Induced SLE--95%- ------
Diffuse Scleroderma---+- +-+-10-20%^40-50%--
CREST Syndrome---- ----^80-90%-
Sjogren.s Syndrome---^70% ^60%+-----
Polymyositis / dermatomyositis---- -----30%

(^) High Titers (%) Frequency of Occurrence (+-) Occasionally Found at Low Titer (-) Usually Not Found

The ImmunoDOT Autoimmunity Screening Panels detect antinuclear antibodies for specific diagnostically significant nuclear antigens and measure individually antibodies to the most common nuclear antigens: deoxyribonucleic acid (DNA), Sjogren's syndrome antigen A (Ro) and antigen B (La), ribonucleoprotein (RNP), Smith (Sm) antigen, Scl-70 antigen and Jo-1 antigen.

The ImmunoWELL DNA Antibody Test is an enzyme immunoassay (EIA) for the quantitative detection of antibodies to double-stranded DNA in serum and is used as an aid in the diagnosis of autoimmune diseases.

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