Anti-Cardiolipin (Phospholipids) Syndrome
Anti-cardiolipin (aCL) autoimmune antibodies are a subset of antibodies which react with
negatively charged phospholipids. Anti-cardiolipin antibodies are frequently observed in
patients with SLE. One autoantibody, LA, is measured with a bioassay and the other
autoantibody, aCL, is measured based on affinity for cardiolipin. In many cases both
autoantibodies are present in a single patient and may be the same antibody in some cases.
During the 1990's the complex interaction of a common serum protein, beta-2 glycoprotein,
and a fatty acid, phosphotydl serine, was defined and shown to be a specific and diagnostic
antibody response. Kits designed before the 1990's did not reliably detect anti-beta-2
glycoprotein, the most significant disease specific component. GenBio's kits not only
detects this important beta-2 glycoprotein reaction, but assures its reproducible and
sensitive measurement by standardizing the phosphotydl serine concentration. This means
the ImmunoWELL Caridiolipin kit reproducibly and simultaneously measures total cardiolipin
and the more significant clinical marker, anti-beta-2 glycoprotein.